Dr. Chittaranjan Yajnik The Bridge Chronicle
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Thin Fat Indian to Epigenetics: New Frontiers in Diabetes Research Unveiled

Socio-economic development combined with micronutrient supplementation for young women is helping reduce excess fat accumulation in babies.

Salil Urunkar

Pune: Dr. Chittaranjan Yajnik, a globally acclaimed diabetes researcher and head of the Diabetes Unit at KEM Hospital, Pune, delivered the 8th Dr. Banoo Coyaji Oration on the topic “Predicting the Future - Horoscope to Molecular Biology.”

He reflected on the unit’s path-breaking research, emphasizing its significant impact on understanding and addressing diabetes in India.

The oration served as a tribute to Dr. Banoo Coyaji, a visionary who played a pivotal role in establishing the diabetes unit at KEM Hospital.

Dr. Yajnik remarked, “Dr. Coyaji’s support and leadership laid the foundation for a thriving unit that excels in diabetes research, patient care, and education. This oration is a public acknowledgment of her invaluable legacy.”

Understanding Diabetes in Indians: Key Findings

Established in 1987 as the first specialized diabetes unit in Western India, the Diabetes Unit has spearheaded several landmark studies.

Dr. Yajnik highlighted the unit’s groundbreaking “Thin Fat Indian” concept, which explains how Indians, despite appearing thin, carry excessive fat in the abdominal region, contributing to a higher prevalence of diabetes.

“Our research, in collaboration with Prof. David Barker, revealed that diabetes risk begins in the womb. Factors such as maternal nutrition, metabolism, and stress play a crucial role in determining the baby’s health,” Dr. Yajnik explained.

The team’s findings also emphasize the importance of balancing Vitamin B12 and folate during pregnancy, leading to interventions aimed at improving maternal health.

He added, “Our trials indicate that socio-economic development combined with micronutrient supplementation for young women is helping reduce excess fat accumulation in babies, marking the beginning of healthier future generations in India.”

Focus on Epigenetics and Policy Advocacy

Dr. Yajnik stated that the unit is now delving into molecular mechanisms, particularly epigenetics, to understand how environmental changes affect gene functions. These findings are expected to shape public health policies and promote better health outcomes on a population scale.

“From research, we aim to transition into advocacy and education, influencing government programs to benefit a larger population,” he noted.

The Diabetes Unit at KEM Hospital continues to lead in patient care, treating thousands with Type 1 and Type 2 diabetes, gestational diabetes, and other specialized conditions.

The unit also runs a robust clinic for Type 1 diabetes, supporting over 1,500 patients, many of whom receive free treatment through charitable donations.

The team has pioneered patient education initiatives, including an active online program for Type 1 diabetes patients and parents, bridging the gap between clinic visits.

The unit’s innovative Madhuraksha app, downloaded by thousands, serves as a vital tool for managing Type 1 diabetes, offering meal and insulin dose calculators and essential self-management tips.

Dr. Yajnik concluded, “Our mission is to ensure that every patient feels empowered to manage their condition effectively. The ongoing advancements in diabetes care and research will continue to benefit individuals and communities alike.”

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